Ukusetyenziswa kweebhotile zesampula ye-TOC: Indlela ye-USP ye-643, ukuvavanywa kwamanzi kwibakala le-pharmaceutical, amanzi e-injection (WFI), amanzi ahlambulukileyo aphezulu (HPW), uvavanyo lokuqinisekisa ukucoca \/ isampuli, ukuvavanya ukusebenza kakuhle ngaphambi nangemva kokucoca, kunye "nomsebenzi omhle wokuvelisa" (GMP) Ukulandelela okufanelekileyo, ukulinganisa kwe-TOC, ukuqinisekiswa kunye nokufaneleka kwenkqubo, ukugcinwa komgangatho wokulinganisa.