HPLC yaying'ono-botolo, yomwe imadziwikanso kuti yaying'ono kwambiri yamadzimadzi chromatography yaying'ono, ndi chidebe chaching'ono chomwe chimagwiritsidwa ntchito mu chemistry yowunikira pakuwunika zitsanzo ndi HPLC. HPLC ndi njira yogwiritsiridwa ntchito kwambiri ya chromatographic yomwe imalekanitsa ndikuwerengera magawo osakanikirana kutengera kuyanjana kwawo ndi gawo loyima komanso gawo la mafoni.
Botolo laling'ono ndi galasi laling'ono kapena chidebe chapulasitiki chopangidwa kuti chizikhala ndi madzi pang'ono a zitsanzo zamadzimadzi, nthawi zambiri mumtundu wa microliters (μL) mpaka mamililita angapo (mL).